Research Progress in Interactions between Bile Acids, Gastrointestinal Microbes and GPBAR1 in Pancreatic Cancer

Bile acids have traditionally been regarded as a contributing factor in the development of pancreatic cancer. However, the mechanisms by which they induce or promote the progression of pancreatic cancer remain controversial. Additional research is necessary to provide substantial evidence. There is evidence that gastrointestinal microbes involved in bile acid metabolism and thw G protein-coupled bile acid receptor (GPBAR1), which responds to bile acid signals, may collaborate with bile acids in the initiation and progression of pancreatic cancer. This review focuses on the relationships between bile acids, gastrointestinal microbes, GPBAR1 and pancreatic cancer. It aims to interpret the factors influencing the onset and development of pancreatic cancer from a holistic perspective and provide insights towards the treatment of pancreatic cancer.