Volume 7 Issue 1
Jun.  2023
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Jia Liu, Peiyan Kong, Lidan Zhu, Shichun Gao, Huanfeng Liu, Lu Wang, Cheng Zhang, Li Gao, Xi Zhang, Lei Gao. Analysis of the clinical efficacy of penciclovir in the prevention of viral infection after allogeneic hematopoietic stem cell transplantation[J]. Blood&Genomics, 2023, 7(1): 55-60. doi: 10.46701/BG.2023012022025
Citation: Jia Liu, Peiyan Kong, Lidan Zhu, Shichun Gao, Huanfeng Liu, Lu Wang, Cheng Zhang, Li Gao, Xi Zhang, Lei Gao. Analysis of the clinical efficacy of penciclovir in the prevention of viral infection after allogeneic hematopoietic stem cell transplantation[J]. Blood&Genomics, 2023, 7(1): 55-60. doi: 10.46701/BG.2023012022025

Analysis of the clinical efficacy of penciclovir in the prevention of viral infection after allogeneic hematopoietic stem cell transplantation

doi: 10.46701/BG.2023012022025
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  • Corresponding author: Xi Zhang and Lei Gao, Medical Center Hematology, Xinqiao Hospital; State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, 83 Xinqiaozheng Street, Shapingba District, Chongqing 400037, China. E-mails: zhangxxi@sina.com and gaolei7765@163.com
  • Received Date: 2022-10-07
  • Rev Recd Date: 2023-03-20
  • Accepted Date: 2023-03-27
  • Available Online: 2023-07-05
  • Publish Date: 2023-06-30
  • This study aims to retrospectively analyze the efficacy of penciclovir in the prevention of viral infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Ninety-six patients with allo-HSCT were enrolled, who were treated at the Medical Center of Hematology of Xinqiao Hospital from June 2020 to September 2021. The experimental and control groups were treated with penciclovir and acyclovir, respectively, to prevent viral infection. By February 2022, the infection rates of cytomegalovirus, BK virus, JC virus, and Epstein-Barr virus (EBV) in the experimental group and the control group were 18.8% and 39.06% (P<0.05), 28.1% and 25% (P>0.05), 6.2% and 7.81% (P>0.05), 21.8% and 23.43% (P>0.05), respectively. The infection-related urinary system symptoms of the experimental group and the control group occurred in 4 and 9 patients, respectively, of which 3 and 9 patients died, respectively. Penciclovir can significantly reduce the cytomegalovirus infection rate after allo-HSCT and has better preventive effects than acyclovir without obvious side effects. The effectiveness and safety of penciclovir will be further verified in the future.

     

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