Volume 5 Issue 2
Dec.  2021
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Article Navigation >  Blood&Genomics  > 2021  >  5(2): 135-145
Qiuyan Xia, Jiajia Jiang, Wei Zhao, Qi Tang, Xiaohua Li, Tengqi Wang, Yan Zhou. Epiregulin promotes growth and metastasis of gastric cancer via the ERK/JNK/p38 signaling pathway[J]. Blood&Genomics, 2021, 5(2): 135-145. doi: 10.46701/BG.2021022021125
Citation: Qiuyan Xia, Jiajia Jiang, Wei Zhao, Qi Tang, Xiaohua Li, Tengqi Wang, Yan Zhou. Epiregulin promotes growth and metastasis of gastric cancer via the ERK/JNK/p38 signaling pathway[J]. Blood&Genomics, 2021, 5(2): 135-145. doi: 10.46701/BG.2021022021125
shu

Epiregulin promotes growth and metastasis of gastric cancer via the ERK/JNK/p38 signaling pathway

doi: 10.46701/BG.2021022021125
  • 1.

    Department of Oncology, the Affiliated Aoyang Hospital of Jiangsu University, Zhangjiagang, Jiangsu 215617, China

  • 2.

    The Center for Pathology & Laboratory Medicine, the Affiliated Aoyang Hospital of Jiangsu University, Zhangjiagang, Jiangsu 215617, China

  • 3.

    Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210001, China

  • 4.

    Key Laboratory of Antibody Techniques of National Health Commission, Nanjing Medical University, Nanjing, Jiangsu 211166, China

  • 5.

    School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China

  • 6.

    The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China

  • 7.

    Cancer Center, Bayannur Hospital, Bayannur, Inner Mongolia 015000, China

More Information
  • Corresponding author: Tengqi Wang, Cancer Center, Bayannur Hospital, Bayannur, Inner Mongolia 015000, China. E-mail: 3571194211@qq.com; Yan Zhou, Department of Oncology, the Affiliated Aoyang Hospital of Jiangsu University, Zhangjiagang, Jiangsu 215617, China. E-mail: yanzhou@yeah.net
  • Received Date: 2021-08-08
  • Accepted Date: 2021-11-29
  • Rev Recd Date: 2021-11-24
    • Available Online: 2022-01-06
  • Publish Date: 2021-12-31
    Abstract
  • Epiregulin (EREG) is a ligand of the epidermal growth factor receptor. It belongs to the ErbB family of ligands found overexpressed in various cancers such as colon cancer and lung carcinoma and is likely to play diverse oncogenic roles in several other cancer types. However, little is known about the mechanisms of EREG in the pathogenesis of gastric cancer (GC). The present study was undertaken to investigate whether EREG influences the development and progression in GC. The results revealed that EREG was found to be overexpressed in human GC cells lines. Moreover, EREG induced cell migration, invasion, and proliferation, and inhibited apoptosis in vitro. The study also found that EREG depletion inhibited tumor growth in vivo. Our findings indicated that EREG activated the ERK/JNK/p38 signaling pathway and PI3K/Akt signaling pathways to promote GC malignant progression. Overall, this study suggests that EREG may promote GC development and progression through the ERK/JNK/p38 and PI3K/Akt signaling pathways, which may improve our understanding of the molecular mechanism of EREG in GC. Thus, EREG may be a potential target for GC treatment.

     

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