Volume 5 Issue 2
Dec.  2021
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Article Navigation >  Blood&Genomics  > 2021  >  5(2): 149-153
Fanghao Liu, Haoyu Li, Yunfeng Miao, Guoli Lv. Treatment of stage IIIB squamous-cell lung cancer with pembrolizumab combined with chemotherapy to achieve pCR: a case report[J]. Blood&Genomics, 2021, 5(2): 149-153. doi: 10.46701/BG.2021022021121
Citation: Fanghao Liu, Haoyu Li, Yunfeng Miao, Guoli Lv. Treatment of stage IIIB squamous-cell lung cancer with pembrolizumab combined with chemotherapy to achieve pCR: a case report[J]. Blood&Genomics, 2021, 5(2): 149-153. doi: 10.46701/BG.2021022021121
shu

Treatment of stage IIIB squamous-cell lung cancer with pembrolizumab combined with chemotherapy to achieve pCR: a case report

doi: 10.46701/BG.2021022021121

  • Department of Geriatric Thoracic Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China

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  • Corresponding author: Guoli Lv, Department of Geriatric Thoracic Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China. E-mail: lvguoli2009@163.com
  • Received Date: 2021-06-28
  • Accepted Date: 2021-12-08
  • Rev Recd Date: 2021-11-24
    • Available Online: 2022-01-06
  • Publish Date: 2021-12-31
    Abstract
  • Lung cancer is currently the leading cause of global cancer-related deaths and its incidence increases every year. Most squamous-cell lung cancers are in the advanced stage at diagnosis. This study reported a case of a 66-year-old man diagnosed with unresectable stage IIIB squamous-cell lung cancer (cT2aN3M0), who was treated with pembrolizumab combined with paclitaxel (albumin-bound) + nedaplatin. After four cycles, a follow-up chest computed tomography (CT) scan showed the disappearance of the original right lower lobe lung mass with cavitation-like changes, and a follow-up chest CT scan 6w later revealed a solid nodule measuring approximately 1.5 cm in diameter within the cavity. Subsequent surgical excision of the residual primary lesion was performed to achieve complete pathological remission. The patient was treated with pembrolizumab combined with paclitaxel (albumin-bound) + nedaplatin and achieved complete pathological remission with surgical excision.

     

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