Volume 5 Issue 1
Jun.  2021
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Lei Liu, Wanbing Liu, Yan Liu, Guomei Kou, Yaqiong Zheng, Liping Cai, Shengdian Wang, Shangen Zheng. Comparative analysis of antibody responses to SARS-CoV-2 in various populations[J]. Blood&Genomics, 2021, 5(1): 41-47. doi: 10.46701/BG.2021012021102
Citation: Lei Liu, Wanbing Liu, Yan Liu, Guomei Kou, Yaqiong Zheng, Liping Cai, Shengdian Wang, Shangen Zheng. Comparative analysis of antibody responses to SARS-CoV-2 in various populations[J]. Blood&Genomics, 2021, 5(1): 41-47. doi: 10.46701/BG.2021012021102

Comparative analysis of antibody responses to SARS-CoV-2 in various populations

doi: 10.46701/BG.2021012021102
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  • Corresponding author: Shengdian Wang, CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Rd, Beijing 100101, China. E-mail: sdwang@ibp.ac.cn; Shangen Zheng, Department of Transfusion Medicine, General Hospital of Central Theater Command of the PLA, 627 Wuluo Rd, Wuhan, Hubei 430070, China. E-mail: sxkzsg@sina.com.
  • Received Date: 2021-01-20
  • Accepted Date: 2021-06-01
  • Rev Recd Date: 2021-04-20
  • Publish Date: 2021-06-01
  • This paper aimed to analyze antibody responses to SARS-CoV-2 in various populations. Two hundred and six COVID-19 patients, 46 convalescent patients, and 270 healthy population were enrolled. Antibodies against nucleocapsid protein (N) and spike protein's receptor-binding domain (RBD), and neutralizing antibody were detected. The results demonstrated both anti-N and anti-RBD antibodies could be detected in about 80% of COVID-19 patients and 90% of convalescent patients, while no antibodies could be detected in some convalescents and patients even after 14 days post-onset of symptoms. The level of anti-RBD antibody strongly correlated with the neutralizing activity of sera from these two cohorts. The titer of neutralizing antibody was lower in convalescents than that in active COVID-19 patients. In addition, the titer of neutralizing antibody was less than 1:80 in none of the severe COVID-19 patients, 18.8% in non-severe COVID-19 patients, and 32.6% in convalescents. The study suggests that the level of anti-RBD antibody is closely related to neutralization activity in COVID-19 patients and convalescents. Some SARS-CoV-2-infected cases trigger a weak antiviral immune response, and the level of neutralizing antibody may have a faster decay rate.


  • These authors contributed equally to this work.
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