The use of apheresis technique to collect platelets has rapidly increased in recent years. With an increased demand for plateletpheresis, higher donation frequencies are now observed. The aim of this study is to investigate changes in complete blood count values after frequent multiple plateletpheresis. A total of seventy-four blood donors were selected, from which complete blood count values in the first and the last screening were taken. There were fifty-four high frequency donors(13.0±2.6 plateletpheresis/year) and twenty low frequency donors(6.6±0.5 plateletpheresis/year). The results showed that complete blood count values at the first and last screening after plateletpheresis of both groups were within the normal range, and changes in their WBC, RBC and PLT values were not statistically significant(P
>0.05, and P
>0.05, respectively). The study suggests that frequent multiple plateletpheresis has no effects on complete blood count, and no adverse effects on blood donors.