Volume 8 Issue 2
Dec.  2024
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Shichun Wang, Qi Liu, Yahan Fan, Yanhong Xin, Shan Wang, Jie Yan, Chunyan Yao. Thromboelastography for Diagnosing Coagulopathy and Guiding Blood Transfusion[J]. Blood&Genomics, 2024, 8(2): 10001. DOI: 10.70322/BG20240210001
Citation: Shichun Wang, Qi Liu, Yahan Fan, Yanhong Xin, Shan Wang, Jie Yan, Chunyan Yao. Thromboelastography for Diagnosing Coagulopathy and Guiding Blood Transfusion[J]. Blood&Genomics, 2024, 8(2): 10001. DOI: 10.70322/BG20240210001
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Thromboelastography for Diagnosing Coagulopathy and Guiding Blood Transfusion

  • 1 Department of Blood Transfusion, the First Affiliated Hospital of Army Medical University, Chongqing 400038, China;

  • 2 Department of Blood Transfusion, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China;

  • 3 Department of Procurement Management, Jinling Hospital, Medical School of Nanjing University, Nanjing 210033, China

Funds: 

This research was funded by the Natural Science Foundation of Chongqing (Grant No. cstc2021jcyj-msxmX0702 and cstb2022nscq-msx0974) and the National Natural Science Foundation of China (Grant No. 81700180).

More Information
  • Author Bio:

    Shichun Wang,E-mail:wangshichun@tmmu.edu.cn;Qi Liu,E-mail:qiliu@tmmu.edu.cn;Yahan Fan,E-mail:fyh@tmmu.edu.cn;Jie Yan,E-mail:18875053243@tmmu.edu.cn;Yanhong Xin,E-mail:victoria080701@163.com;Shan Wang,E-mail:434685486@qq.com

  • Corresponding author:

    Chunyan Yao,E-mail:yaochunyan@tmmu.edu.cn

  • Received Date: 2024-05-08
  • Revised Date: 2024-08-27
  • Available Online: 2024-12-26
  • Published Date: 2025-06-07
    Graphical Abstract
    • Abstract
  • Timely response to coagulopathy could provide the best objective evidence to guide therapies, predict bleeding and thrombotic risk, reduce the cost of care, and improve outcomes. This review sought to identify the diagnostic characteristics of Thromboelastography (TEG) in bleeding and hypercoagulability populations and the guiding principle for blood components transfusion. We reviewed the research studies of TEG in bleeding diseases (trauma, cardiac surgery, and liver surgery) and hypercoagulability populations (obstetric patients, older patients, and infection patients). We also summarized its guiding principle for blood components transfusion (whole blood, platelet, plasma, and cryoprecipitate). Overall, TEG can diagnose surgical bleeding and hypercoagulability population by recognizing the alterations of the coagulation system, e.g., long R, flat α angle, thin maximum amplitude (MA), and increased LY30 in initial severe bleeding trauma patient; shortened R, increased α and MA, shortened K when patient with endothelial injury; decrescent K, increscent α angle, MA and coagulation index (CI) in people over 50 years. TEG can also guide blood transfusion. For example, TEG MA < 55 mm can be a threshold for platelet transfusions for thrombocytopenia patients; one unit of FFP shortens the R time by 5 minutes with a ratio of 5 mins/U of FFP for high-responder surgical patients. TEG can help diagnose coagulopathy and guide blood transfusion. However, there are still challenges and prospects for the clinical applications of TEG, such as achieving faster results and developing realistic blood flow detection environments. We expect that advances in mathematics, physics, and medical analysis will be integrated into patient blood management.
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    • References (81)
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