The transcription factor E2F2 regulates tumor development

Cell cycle-related E2F transcription factor 2 (E2F2) is a member of the E2F transcription factor family. E2F2 is implicated in tumorigenesis as it functions as a nuclear transcription factor responsible for regulating cell cycle progression to maintain genomic integrity. In recent decades, substantial experimental evidence has associated the function of E2F2 with tumor promotion. However, this transcription factor has also been revealed to be capable of exerting tumor suppressive activities in certain tumor models. In this review, we discuss recent developments in research that focus on E2F2 with respect to tumorigenesis. We will particularly address the dynamic regulatory roles of microRNA (miRNA) on the expression of E2F2 as various miRNA species have been confirmed to have complementary binding sites in the 3' untranslated region of E2F2.