Research progress of antibiotic misuse and anti-antibiotic antibodies

Antibiotic misuse has escalated globally, posing significant threats to public health. This rampant misuse not only fuels antibiotic resistance but also triggers the formation of anti-antibiotic antibodies, which may cause severe complications such as immune-mediated hemolytic anemia and compromise therapeutic efficacy. This review provides an in-depth analysis of this critical issue, evaluating both theoretical and clinical evidence regarding the emergence of these antibodies and elucidating their impact on clinical pharmacotherapy and severe complications, particularly in immune-mediated hemolytic anemia. Additionally, it underscores the growing challenge of antibiotic resistance and the pressing necessity for effective strategies to address this global health crisis.