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Min Song, Zhenrui Xue, Yahan Fan, Ziyi Xia, Chenxi Liu, Linxiao Yan, Chunyan Yao. Significance of alanine aminotransferase testing in blood donor screening in Chongqing, China: a 7-year retrospective analysis[J]. Blood&Genomics. doi: 10.46701/BG.2023022023016
Citation: Min Song, Zhenrui Xue, Yahan Fan, Ziyi Xia, Chenxi Liu, Linxiao Yan, Chunyan Yao. Significance of alanine aminotransferase testing in blood donor screening in Chongqing, China: a 7-year retrospective analysis[J]. Blood&Genomics. doi: 10.46701/BG.2023022023016
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Significance of alanine aminotransferase testing in blood donor screening in Chongqing, China: a 7-year retrospective analysis

doi: 10.46701/BG.2023022023016
  • 1.

    Department of Transfusion Medicine, Southwest Hospital, Army Medical University, Chongqing 400038, China

  • 2.

    Department of Otolaryngology, Southwest Hospital, Army Medical University, Chongqing 400038, China

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  • Corresponding author: Chunyan Yao, Department of Transfusion Medicine, Southwest Hospital, Army Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China. E-mail: yaochunyan@tmmu.edu.cn
  • Received Date: 2023-08-04
  • Rev Recd Date: 2023-09-05
  • Accepted Date: 2023-09-26
    • Available Online: 2023-11-01
    Abstract
  • Since 1993, alanine aminotransferase (ALT) testing has been mandatory for blood donor screening in China. This study aimed to evaluate the significance of ALT testing for transfusion safety. Between January 2012 and December 2018, 122236 blood donor samples were routinely screened by the enzyme-linked immunosorbent assay method for transfusion-transmitted disease markers (TTDM) and by the kinetics method for ALT. Out of 2705 (2.21%) seropositive donors, 291 (10.76%) tested positive for ALT alone and were categorized as ALT-only positive donors. Fourteen ALT-only positive donors who all tested negative in subsequent TTDM and nucleic acid testing (NAT) screening were followed up. The return rate for ALT-only positive donors was reduced by 4.1 times as compared with qualified blood donors (P<0.000). The results suggest that ALT testing does not make a significant contribution to reducing the risk of transfusion-transmitted diseases. Furthermore, being disqualified even once owing to elevated ALT levels has a significant impact on donors' return behavior. Therefore, a suitable cutoff value for ALT testing should be considered based on the evaluated risk in both blood safety and supply.

     

    • △The authors contributed equally to this work.
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