Incidence of piperacillin-specific drug antibody in patients with and without piperacillin

The aim of this study was to investigate the incidence of piperacillin-specific drug antibody in patients with and without piperacillin. Piperacillin antibody was detected by piperacillin-induced hemolysis test kit. Three hundred samples were collected from patients who had been treated with piperacillin within 3 months; and 222 samples were from patients who were treated with other antibiotics; and a normal group of 120 samples was from healthy blood donors. The results showed that the positive rates in the piperacillin group, the other antibiotic group and the control group were 11.33%, 4.95% and 1.67%, respectively, which was statistically significant. The antibody titer was from 2 to 64. The antibody titer of the piperacillin group was significantly higher than that of the other two groups. The study suggests that piperacillin is able to induce piperacillin-specific drug antibody and drug antibody detection is useful for maintaining the safety of medication.