The Research Progresses of Mesenchymal Stem Cells Therapy in Hematological Diseases

Hematopoietic diseases are characterized by the high heterogeneity of associated hematopoietic cells, which mainly affect the homeostasis of the hematopoietic system. Due to their potential for multilineage differentiation and expected immunomodulatory properties, mesenchymal stem cell (MSC) based therapies have demonstrated significant promise in treating hematologic diseases. They have been successfully applied in various conditions, including aplastic anemia, refractory/relapsed myeloid leukemia, immune thrombocytopenic purpura, etc. Therefore, the purpose of this article is to review the biological characteristics, clinical applications, and related mechanisms of MSCs in hematopoietic diseases.